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. 2021 Aug 16;6:303. doi: 10.1038/s41392-021-00714-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Acetylation-defective SerRS Lys³²³-to-Arg (Sars^K/R) heterozygote knock-in mice exhibit increased body weight and adiposity. a Representative images of a Sars^K/R mouse showing bigger body size than the wild type Sars^K/K littermate at 25 weeks. b Growth curves of Sars^K/R and Sars^K/K mice (n = 8, mean ± SEM, ***P < 0.0001, by two-way ANOVA). c Weights of the inguinal (Ing), perigonadal (Per), retroperitoneal (Ret), and mesenteric (Mes) white adipose tissues (WAT) and interscapular brown adipose tissue (BAT) from 18-week female mice fed a standard diet (means ± SEM, n = 6, **P < 0.01, ***P < 0.001, ns indicates not significant, by unpaired Student’s t-test). d Weights of the indicated major organs from 18-week female mice fed a standard diet (means ± SEM, n = 6, *P < 0.05, ns indicates not significant, by unpaired Student’s t-test,). e Histological staining analysis of indicated WAT in 18-week old female Sars^K/R and Sars^K/K mice and the quantification (***P < 0.0001, by unpaired Student’s t-test)