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. 2021 Aug 16;12:4950. doi: 10.1038/s41467-021-25248-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic diagram of the ligand-induced type I/type II receptor tetramer and resulting regulatory Gly/Ser rich (GS) domain phosphorylation. Pink dots symbolize phosphorylated residues within the GS domain. b Diagram depicting the domain boundaries within the ALK2 and BMPR2 receptors, including the extracellular domain (ECD), transmembrane (TM) helix, the GS domain, and the kinase domains (KD). Residues marking kinase domain boundaries and boundaries of the constructs used in this study are marked. c Size-exclusion chromatograms of ALK2^KD (cyan), BMPR2^KD (orange) and the ALK2^KD/BMPR2^KD complex (black) resolved on a Superdex 200 Increase 10/300 GL column. Molecular weight standards are indicated above: 1— γ-globulin (158,000 Da), 2—ovalbumin (44,000 Da) and 3—myoglobin (17,000 Da). d The radius of gyration (R_g) calculated from the crystal structures of ALK2 (PDB ID: 3MTF) and BMPR2 (PDB ID: 3G2F) compared with molecular dimensions calculated from the SEC-SAXS profiles of the ALK2^KD, BMPR2^KD, and the ALK2^KD/BMPR2^KD complex. e SAXS P(r) function of ALK2^KD (cyan), BMPR2^KD (orange), and the ALK2^KD/BMPR2^KD (black) complex.