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. 2021 Aug 16;11:16580. doi: 10.1038/s41598-021-96217-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Functional characterization of SERCA2a activators in human iPSC-derived cardiomyocytes. Concentration-dependent effects of SERCA2a activators CP-154526, CDN1163, and Ro 41–0960 on (A) the Ca²⁺ transient amplitude, (B) the Ca²⁺ transient duration at 50% recovery (CaTD₅₀), and (C) beat rate in normal human iPSC-derived cardiomyocytes. We compared these effects to those induced by isoproterenol (ISO), which has both positive inotropic and chronotropic effects on the cardiomyocyte. Results are expressed as percent change from baseline values in Hank’s balanced salt solution and reported as mean ± SEM (n = 6). Groups were compared using a one-way analysis of variance (ANOVA) with the Dunnett test.