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. 2021 Aug 16;4:974. doi: 10.1038/s42003-021-02498-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Analysis of proteins from HeLa cells treated with siRNAs. The cells were used for experiments 3 d after the second transfection, Left panel, immunoblot analysis of total proteins from cells was carried out as described in the legend to Fig. 1a. Right panel, immunoblot analysis of soluble (S) and insoluble (I) proteins in the knockdown cells was carried out as described in the legend to Supplementary Fig. S2. b Model of LONP1 activity toward imported proteins. Left panel, LONP1 associates with incoming proteins. Right panel, LONP1 assists folding and/or assembly of the imported proteins using its chaperone-like activity. Unprocessed imported proteins are degraded by LONP1. Imported proteins aggregate in the mitochondrial matrix of LONP1 knockdown cells or LONP1 dominant negative cells.