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. 2021 Aug 16;11:16582. doi: 10.1038/s41598-021-95712-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MiR-181c-5p promoted hyperoxia-induced apoptosis of LMECs by inhibiting the expression of its target gene NCAPG. (a) Comparison of apoptosis of LMECs treated with miR-181c-5p mimic (miR-181c-5p) or inhibitor (IHB) and the corresponding negative control sequences (NC, NC-IHB). ▲: p < 0.001 versus all other groups. (b) Comparison of expression levels of NCAPG mRNA in LMECs with different treatments. ▲: p < 0.001 versus all other groups; #: p < 0.01 versus all other groups. (c) Comparison of apoptosis of LMECs with different treatments. △: p < 0.001 versus all other groups except for miR-181c-5p + empty vector group; ▼: p < 0.001 versus all other groups except for miR-181c-5p group; ▲: p < 0.001 versus all other groups. (d) Relative changes of apoptosis of hyperoxia-treated LMECs transfected with miR-181c-5p mimic (miR-181c-5p) or inhibitor (IHB) and the corresponding negative control sequences (NC, IHB-NC). ▲: p < 0.001 versus all other groups; #: p < 0.01 versus all other groups. (e) Relative changes of apoptosis of hyperoxia-treated LMECs transfected with miR-181c-5p or different vectors. #: p < 0.01 versus all other groups; ▲: p < 0.001 versus all other groups; △: p < 0.001 versus all other groups except for miR-181c-5p + empty vector group; ▼: p < 0.001 versus all other groups except for miR-181c-5p group; §: p < 0.001 versus all other groups except for empty vector group. Data are presented as mean ± SEM. One-way ANOVA analysis with Tukey's post hoc test was used for statistical analysis.