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. 2021 Aug 16;11:16582. doi: 10.1038/s41598-021-95712-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Lnc-DLEU2 inhibited hyperoxia-induced apoptosis of LMECs through a ceRNA network. (a,b) The relative expression levels of NCAPG at mRNA (a) and protein (b) levels in hyperoxia-treated LMECs with different treatments compared to the untreated (a) or hyperoxia-treated (b) LMECs. ***: p < 0.001 versus all other groups; #: p < 0.05 versus all other groups. (c) Relative changes of apoptosis of hyperoxia-treated LMECs with different treatments compared to the untreated LMECs. ***: p < 0.001 versus all other groups. (d) Relative changes of apoptosis of hyperoxia-treated LMECs transfected with lnc-DLEU2 vector, miR-181c-5p mimic and/or inhibitor as well as the corresponding negative control sequences. The untreated LMECs were used as control. ***: p < 0.001 versus all other groups. (e) Relative changes of apoptosis of hyperoxia-treated LMECs transfected with lnc-DLEU2 vector, and/or NCAPG vectors or siRNA. The untreated LMECs were used as control. **: p < 0.01 versus all other groups. ***: p < 0.001 versus all other groups. (f) The schematic diagram of the pro-apoptotic effects of miR-181c-5p through a ceRNA network consisted of lnc-DLEU2, miR-181c-5p and NCAPG in LMECs. The red rectangle indicated upregulated, blue rectangle indicted downregulated. Data are presented as mean ± SEM. One-way ANOVA analysis with Tukey's post hoc test was used for statistical analysis.