Table 4.
PPVs when one assay or two combined assays were positive for five exemplary populations with 10%, 5%, 2%, 1%, and 0.1% SARS-CoV-2 prevalence
| PPV (%) when one assay or two combined assays are both positive* | |||||
|---|---|---|---|---|---|
|
| |||||
| SARS-CoV-2 10% prevalence | SARS-CoV-2 5% prevalence | SARS-CoV-2 2% prevalence | SARS-CoV-2 1% prevalence | SARS-CoV-2 0.1% prevalence | |
| Roche | 97.3 (†90.8) | 94.4 (†82.4) | 86.7 (†64.4) | 76.3 (†47.2) | 24.2 (†8.2) |
| Abbott | 94.6 (†87.4) | 89.3 (†76.6) | 76.0 (†56.0) | 61.6 (†38.6) | 13.7 (†5.9) |
| Siemens | 100 (†95.2) | 100 (†90.3) | 100 (†78.4) | 100 (†64.2) | 100 (†15.1) |
| SD Biosensor | 93.7 (†86.5) | 87.6 (†75.2) | 73.2 (†54.1) | 57.5 (†36.8) | 10.8 (†5.5) |
| LG Chem | 80.3 (†72.2) | 65.9 (†55.2) | 42.8 (†32.3) | 27.0 (†19.1) | 3.5 (†2.3) |
| Roche+Abbott | 100 (†99.8) | 100 (†99.7) | 99.9 (†99.1) | 99.8 (†98.2) | 98.1 (†84.7) |
| Roche+Siemens | 100 (†99.9) | 100 (†99.9) | 100 (†99.7) | 100 (†99.4) | 100 (†94.0) |
| Roche+SD Biosensor | 100 (†99.8) | 100 (†99.6) | 99.9 (†99.1) | 99.8 (†98.1) | 97.7 (†83.6) |
| Abbott+Siemens | 100 (†99.9) | 100 (†99.8) | 100 (†99.6) | 100 (†99.1) | 100 (†91.7) |
| Abbott+SD Biosensor | 100 (†99.7) | 99.9 (†99.5) | 99.8 (†98.7) | 99.5 (†97.3) | 95.5 (†78.2) |
| Siemens+SD Biosensor | 100 (†99.9) | 100 (†99.8) | 100 (†99.5) | 100 (†99.0) | 100 (†91.1) |
*Calculated using online calculators on the US Food and Drug administration [13]; †PPVs calculated using the lowest value of the 95% CI of the calculated specificity are shown in parentheses.
Abbreviations: CI, confidence interval; PPV, positive predictive particle; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.