Fig. 4.

HY1702 attenuates mild acute respiratory distress syndrome in mice. Mice were intragastrically administratered with HY1702 (5, 10 or 30 mg/kg), dexamethasone (5 mg/kg) or vehicle 1 h before lipopolysaccharide challenge. 6 h after lipopolysaccharide administration, bronchial alveolar lavage fluid, and lung tissue were collected to quantify the tumor necrosis factor-α, interleukin-1β and interleukin-6 expression by enzyme-linked immunosorbent assay (A) and verse transcription-polymerase chain reaction (B). C: Effects of HY1702 on the lung wet to dry weight ratio in lipopolysaccharide-induced mild acute respiratory distress syndrome. D: Effects of HY1702 on protein content of bronchial alveolar lavage fluid in lipopolysaccharide-induced mild acute respiratory distress syndrome. The values presented are mean ± S.E.M (n = 6) of three independent experiments. ^##P < 0.01, ^###P < 0.001 compared with control; * P < 0.05, ** P < 0.01, ***P < 0.001 compared with LPS mode.