REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-GFAP-cy3	Millipore Sigma	C9205; RRID:AB_476889
Rabbit anti-p-p44/42 MAPK Erk1/2	Cell Signaling	4370; RRID:AB_2315112
Mouse anti-p44/42 MAPK Erk1/2	Cell Signaling	9107; RRID:AB_10695739
Chicken-Anti Vimentin	Abcam	ab24525; RRID:AB_778824
IRDye 680RD	Li-cor	926-68073; RRID:AB_10954442
IRDye 800CW	Li-cor	926-32212; RRID:AB_621847
Chemicals, peptides, and recombinant proteins
DMSO	Fisher Scientific	676.85
Bovine Serum Albumin	Sigma	A9647
TritonX-100	Sigma	T9284
Normal Donkey serum	Jackson Immunoresearch	017-000-121
Recombinant FGF1	Prospec Protein Specialists	CYT-528
FGF19	Phoenix Pharmaceuticals	073-41
U0126	Millipore Sigma	662005
T-PER Tissue Protein Extraction Reagent	Thermo Scientific	78501
Intercept Blocking Buffer	Li-cor	927-60001
4x protein loading buffer	Li-cor	928-40004
Critical commercial assays
BCA Protein Assay Kit	Thermo Scientific	23225
Revert 700 Total protein Stain Kit	Li-cor	P/N: 926-11010
Deposited data
sc-RNA seq Raw data	This paper	GEO: GSE153551
Experimental models: Organisms/strains
C57BL/6J	Jackson Laboratories	Stock No. 000664
B6.V-Lepob/J homoxygous	Jackson Laboratories	Stock No. 000632
B6.V-Lepob/ob/JRj	Janvier Labs	B6.V-Lepob/ob/JRj
Software and algorithms
R -project	R Foundation for Statistical Computing	R version 4.0.2
Prism	GraphPad	7.0e
Other
Lateral Ventricle Cannula	Plastics One	8IC315GAS5C C315GAS-5/SPC
Lateral Ventricle Injector	Plastics One	8lC3151AS5SC C3151AS-5-SPC
Dummy cannula	Plastics One	8IC315DCSXXC
Third Ventricle Cannula	Plastics One	8IC315GAS5C C315GAS-5/SPC cut 6.3 mm below pedestal
Third Ventricle injector	Plastics One	8IC315IAS5SC C315IAS-5/SPC 33GA
Bone Screws	Plastics One	8L0X3905201F
Micro-osmotic pump	Alzet	Model 1003D