Fig. 2.

Literature-based SL pairs analysis in the study cohort (A) Representation of main variables of 4,950 tumor samples across 27 tumor types from the study cohort. Processed data and variables as in Ciani et al. [25]. (B) Circos plot of literature-based synthetic lethal pairs; black lines highlight those scored as mutually exclusive by FaME in the study cohort (left). For each of the latter, a pan-cancer oncoprint color-coded based on tumor allele specific genomic status and significant tumor type (center) is shown. Boxplot report the statistics for mutual exclusivity of all genomic combinations in the specific tumor type or at the pan-cancer level (Sign. dataset column). Gain, hemi deletions, CN-LOH, SNVs were considered.