Table 3:
SCD-related complications as Predictive Variables for Neurodevelopmental Disorders
| Model A | Model B | ||||||
|---|---|---|---|---|---|---|---|
| Variable | N | Unadjusted Odds Ratio | 95% Confidence Interval | p-value | Adjusted Odds Ratio | 95% Confidence Interval | p-value |
| Seizure | 8 | 6.81 | 1.81 – 25.64 | 0.005 | 7.11 | 1.92 – 26.3 | 0.003 |
| Stroke | 19 | 4.75 | 2.02 – 11.14 | <0.001 | 3.13 | 1.48 – 6.69 | 0.003 |
| Dactylitis | 17 | 3.19 | 1.44 – 7.06 | 0.004 | 5.56 | 2.47 – 12.49 | <0.001 |
| Pain Crises | 55 | 2.67 | 1.21 – 5.9 | 0.015 | 2.67 | 1.23 – 5.77 | 0.013 |
| Asthma | 23 | 1.9 | 0.93 – 3.88 | 0.08 | |||
| Headache | 9 | 1.63 | 0.58 – 4.52 | 0.35 | |||
| Retinopathy | 8 | 1.36 | 0.51 – 3.62 | 0.54 | |||
| Acute Chest Syndrome | 35 | 0.99 | 0.51 – 1.93 | 0.97 | |||
| Splenic Sequestration | 7 | 0.86 | 0.31 – 2.35 | 0.76 | |||
Dependent variable: Presence or Absence of Neurodevelopmental Disorders
Independent variables: History of seizure, dactylitis, stroke, pain crisis, asthma, headache, retinopathy, acute chest syndrome, splenic sequestration