Table 4:

SCD-related complications as Risk Factors for Neurodevelopmental Disorders

Model C
Variable	N	Unadjusted Odds Ratio	95% Confidence Interval	p-value	Adjusted Odds Ratio	95% Confidence Interval	p-value
Stroke	19	5.81	2.71 – 12.44	<0.001	4.75	2.15 – 10.46	<0.001
Seizure	8	7.26	2.11 – 24.99	0.002	6.5	1.85 – 22.87	0.004
Headache	9	2.26	0.93 – 5.5	0.072	1.86	0.74 – 4.67	0.18
Retinopathy	8	1.51	0.62 – 3.64	0.37	0.88	0.34 – 2.32	0.8
Pain Crises	55	3.36	1.62 – 6.96	0.001	2.87	1.33 – 6.21	0.007
Dactylitis	17	2.64	1.32 – 5.27	0.006	3.42	1.64 – 7.14	0.001
Splenic Sequestration	7	0.99	0.4 – 2.42	0.98	0.97	0.39 – 2.4	0.94
Acute Chest Syndrome	35	1.48	0.85 – 2.59	0.17	1.28	0.72 – 2.28	0.41
Asthma	23	2.2	1.2 – 4.06	0.011	1.91	1.02 – 3.58	0.04
Model D
Neurovascular	76	4.41	2.44 – 7.98	<0.001	3.84	1.99 – 7.4	<0.001
Pain	196	3.16	1.48 – 6.74	0.003	2.68	1.22 – 5.92	0.014
Other	34	1	0.43 – 2.33	1	0.96	0.41 – 2.28	0.93
Pulmonary	147	1.56	0.88 – 2.74	0.13	1.3	0.72 – 2.35	0.38

Groups were characterized as Neurovascular (Stroke, Seizure, Headache, Retinopathy), Pain (Pain Crises, Dactylitis), Other (Splenic Sequestration, Avascular Necrosis), and Pulmonary (Acute Chest Syndrome, Asthma).

Dependent variable: History of seizure, dactylitis, stroke, pain crisis, asthma, headache, retinopathy, acute chest syndrome, splenic sequestration

Independent variables: Presence or Absence of Neurodevelopmental Disorder

Both models were adjusted for age at time of chart review and gender.