Table 1.

Activity of compounds in the training set mapped to the pharmacophore model.

Comp.	PDB ID	Potency measure	Potency human MDM2 (nM)
TS-1	3VZV [24]	IC50	9.2
TS-2	4IPF [25]	IC50	18
TS-3	4OBA [12]	IC50	0.4
TS-4	4OQ3 [26]	IC50	8
TS-5	3LBL [27]	K i	3
TS-6	4DIJ [8]	IC50	30
TS-7	4ERE [28]	IC50	4.2