Table 4.

In vitro antiproliferative activities of compounds AO-476/43250177, AG-690/37072075, AK-968/15254441, AO-022/43452814, and AF-399/25108021.

Comp.	Specs ID	IC50 (μM) ± SD
		MCF7 (p53 +/+)	MCF7 (p53 -/-)	HCT116 (p53 +/+)	HCT116 (p53 -/-)
2	AO-476/43250177	>100	>100	35.52 ± 1.48	58.19 ± 4.57
5	AG-690/37072075	40.17 ± 1.77	56.42 ± 4.12	17.37 ± 1.80	40.81 ± 3.54
8	AK-968/15254441	>100	>100	>100	>100
10	AO-022/43452814	19.35 ± 2.26	26.73 ± 1.65	12.63 ± 2.32	24.14 ± 2.31
15	AF-399/25108021	>100	>100	28.12 ± 2.53	51.69 ± 4.15
Nutlin-3a	—	32.18 ± 1.49	53.36 ± 2.81	18.13 ± 2.17	40.72 ± 1.47