Table 1.
The top 10 related candidate drugs for Alzheimer's disease, obesity, asthma, epilepsy, and Parkinson's disease
| Disease name | Rank | Drug name | Description | Rank | Drug name | Description |
|---|---|---|---|---|---|---|
| Alzheimer's disease | 1 | corticotropin | CTD_I | 6 | ergoloid | 36, 37, 38, 39, 40 |
| 2 | natalizumab | N/A | 7 | fludrocortisone | CTD_I | |
| 3 | dexamethasone | CTD_I | 8 | prednisone | CTD_I | |
| 4 | teriflunomide | N/A | 9 | budesonide | CTD_I | |
| 5 | canakinumab | 41, 42, 43, 44, 45 | 10 | dalfampridine | CTD_I | |
| Obesity | 1 | lisdexamfetamine | CTD_I | 6 | nicotine | CTD_M |
| 2 | methylphenidate | CTD_I | 7 | guanfacine | CTD_I | |
| 3 | dextroamphetamine | CTD_I | 8 | naloxegol | N/A | |
| 4 | atomoxetine | 46, 47, 48, 49, 50, 51 | 9 | methylnaltrexone | 52,53 | |
| 5 | dexmethylphenidate | N/A | 10 | disulfiram | CTD_I | |
| Asthma | 1 | zileuton | CTD_T | 6 | ipratropium bromide | CTD_T |
| 2 | salbutamol | CTD_T | 7 | arformoterol | CTD_T | |
| 3 | montelukast | CTD_T | 8 | fluticasone propionate | CTD_T | |
| 4 | formoterol | CTD_T | 9 | dexpanthenol | CTD_I | |
| 5 | salmeterol | CTD_T | 10 | ephedrine | CTD_T | |
| Epilepsy | 1 | lorazepam | DrugBank_T | 6 | oxcarbazepine | CTD_T |
| 2 | clonazepam | CTD_T | 7 | levetiracetam | CTD_T | |
| 3 | ethosuximide | CTD_T | 8 | tiagabine | CTD_I | |
| 4 | stiripentol | DrugBank_T | 9 | nitrazepam | CTD_T | |
| 5 | topiramate | CTD_T | 10 | ethotoin | 54,55 | |
| Parkinson's disease | 1 | pergolide | CTD_T | 6 | octreotide | CTD_I |
| 2 | metixene | DrugBank_T | 7 | cabergoline | CTD_T | |
| 3 | orphenadrine | CTD_T | 8 | gabapentin | CTD_T | |
| 4 | rivastigmine | CTD_T | 9 | lanreotide | 56 | |
| 5 | gabapentin enacarbil | 57,58 | 10 | pegvisomant | N/A |
CTD_I, inferred; CTD_M, curated (marker/mechanism); CTD_T, curated (therapeutic); DrugBank_T, therapeutic; N/A, could not be confirmed.