Fibrotic remodeling of epicardial adipose tissue (EAT) and adipocyte diameter. A: (a) Representative photomicrograph of excised left atrial appendage, and (b)(c) sections with Masson’s trichrome staining. B: Representative photomicrographs of (a) immunostaining for α-SMA (red arrows), (b) transmission electron microscope imaging, (c) immunostaining for CD68 (yellow arrows) and CD3 (silver arrows). CD68, green; CD3, red and DAPI, blue. (d)–(f) Corresponding quantitative analysis of (a)–(c). C: (a) Representative cases and (b)(c) corresponding quantitative analysis. C-EAT = central EAT; Endo = endocardium; Epi = epicardium; M-EAT = marginal EAT.