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. 2021 Aug 17;19:352. doi: 10.1186/s12967-021-03014-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Features of TIME in different subtypes. A Based on the results of ssGSEA in LGG samples, the difference of enrichment score of each sample changes in IS1, IS2, and IS3, as the heatmap showed. B The difference of enrichment score of each sample changes in IS2 and IS2 shown in the boxplots. C The difference analysis of the abundance of immune cells and the level of the stromal, immune score on IS1, IS2, and IS3. D The difference analysis of the abundance of immune cells and the level of the stromal, immune score on IS2 and IS3. E The different expression levels of ICP genes in IS1, IS2, and IS3. F The different expression levels of ICD-related genes among three subtypes. *** p < 0.001, ** p < 0.01, * p < 0.05, ns: not significant