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. 2021 Aug 3;11:712105. doi: 10.3389/fcimb.2021.712105

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Copyright © 2021 Rios, Casciato, Caldirola, Gaillard, Giadans, Ameigeiras, De Matteo, Preciado and Valva

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between intrahepatic infiltrate and liver damage. Portal–periportal cell population frequencies related to hepatitis (A–C) and fibrosis severity (D–F). Lobular cell population frequencies related to hepatitis (G, H) and fibrosis severity (I, J). Th, CTL, B lymphocytes and NK cell (A, D, G, I); Th subpopulation (B, E, H, J); and total portal lymphocytes (C, F). MM, minimal–mild; MS, moderate–severe hepatitis. Advanced fibrosis (F≥3) according to METAVIR. The results are depicted in box plots. Horizontal lines within boxes indicate medians. Horizontal lines outside the boxes represent the 5 and 95 percentiles. Mean is indicated as +. Mann–Whitney U test was used to compare all data sets, except for portal–periportal CTL, B, Th1, and Treg cells vs. hepatitis severity, and CTL and B cell vs. fibrosis severity for which Student’s t-test was applied.