Table 2.

Relative abundance of selected microbial taxa in patients with and without SAP in the training cohort.

Taxa	Relative abundance (%)			Univariate		Multivariate
The taxa increased in SAP	SAP	non-SAP	P value	OR (95% CI)	AUC	Model 1*aOR (95% CI)	Model 2†aOR (95% CI)
Phylum Proteobacteria	12.04	8.19	0.008	3.00 (1.28-7.00)	0.624	NA	NA
Class Gammaproteobacrteria	9.60	5.37	0.003	2.91 (1.44-5.85)	0.641	NA	3.79 (1.19-12.13)
Class Bacilli	0.67	0.51	0.011	2.20 (1.27-3.83)	0.620	2.65 (1.08-6.49)	2.80 (1.19-6.56)
Order Lactobacillales	0.67	0.51	0.011	2.20 (1.27-3.83)	0.620	2.65 (1.08-6.49)	2.80 (1.19-6.56)
Order Enterobacteriales	9.22	4.77	0.004	2.66 (1.35-5.25)	0.635	NA	3.78 (1.19-11.95)
Family Enterococcaceae	0.32	0.14	<0.001	2.35 (1.44-3.86)	0.701	2.58 (1.27-5.25)	1.98 (1.10-3.60)
Family Porphyromonadaceae	3.31	2.16	0.023	2.63 (1.09-6.36)	0.607	NA	NA
Family Enterobacteriaceae	9.22	4.77	0.004	2.66 (1.35-5.25)	0.635	NA	3.78 (1.19-11.95)
Genus Erwinia	0.099	0.057	0.003	1.32 (0.97-1.80)	0.642	2.08 (1.23-3.51)	2.07 (1.25-3.43)
Genus Enteococcus	0.324	0.135	<0.001	2.35 (1.44-3.86)	0.701	2.58 (1.27-5.25)	1.98 (1.10-3.60)
Genus Bilophila	0.387	0.274	0.010	2.64 (1.30-5.38)	0.622	3.75 (1.22-11.57)	4.94 (1.36-17.92)
Genus Parabacteroides	3.31	2.16	0.023	2.63 (1.09-6.36)	0.607	NA	NA
The taxa decreased in SAP
Genus Roseburia	0.13	0.29	<0.001	0.50 (0.33-0.78)	0.701	0.52 (0.30-0.90)	0.56 (0.34-0.93)
Microbial Dysbiosis Index (MDI)‡	2.6	2.1	<0.001	2.17 (1.45-3.25)	0.750	1.95 (1.19-3.20)	1.90 (1.18-3.04)

*Adjusted with P <0.10 in univariate analysis (age, hyperlipidemia, AF, dysphagia, white blood cell, neutrophil, lymphocyte, NLR, TOAST and initial NIHSS score).

†Adjusted with P<0.10 in the univariate analysis and A2DS2 (hyperlipidemia, white blood cell, neutrophil, lymphocyte, NLR, TOAST and A2DS2 score).

‡Index of Microbial dysbiosis (showed as median), not relative abundance.

NA, not assessed.