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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Expert Opin Drug Metab Toxicol. 2021 Jun 30;17(7):767–784. doi: 10.1080/17425255.2021.1940952

Table 1.

Human cytosolic sulfotransferases (SULTs) with their amino acid sequence length, gene location on chromosomes, substrate specificity and gene cloning timeline.

SULT1 No. of AA2 Gene Location on Chromosome Prototype Substrate References
1A1 295 16p12.1 p-Nitrophenol Wilborn et al., 1993; Dooley et al., 1994;
1A2 295 16p12.1 p-Nitrophenol Zhu et al., 1996; Her et al., 1996
1A3 295 16p11.2 Dopamine Dooley et al., 1994; Aksoy and Weinshilboum, 1995
1B1 296 4q13.3 Iodothyronines Fujita et al., 1997
1C2 296 2q12.3 p-Nitrophenol Her et al., 1997; Sakakibara, 1998
1C3 304 2q12.3 Bile acids; iodothyronines Freimuth et al., 2000; Kurogi et al., 2017
1C4 302 2q12.3 p-Nitrophenol Freimuth et al., 2000; Sakakibara et al., 1998
1E1 294 4q13.1 17β-estradiol Aksoy et al., 1994
2A1 285 19q13.3 DHEA1 Otterness et al., 1992; Kong et al., 1992
2B1a 350 19q13.3 Pregnenolone Her et al., 1998
2B1b 365 19q13.3 Cholesterol Her et al., 1998
4A1 284 22q13 unknown Walther et al., 1999; Falany et al., 2000
6B1 265 2p22.3 unknown Freimuth et al., 2004
1

Dehydroepiandrosterone