Table 2.
Summary of differential sulfating activities of human SULT allozymes toward endogenous hormones and drugs.
| SULT | Allozymes | Effects on the activities with hormones and drugs | References |
|---|---|---|---|
| 1A1 | Arg37Gln | acetaminophen (↓)*, O-desmethylnaproxen (↓)2 | 78 |
| Pro47Ser | acetaminophen (↓), O-desmethylnaproxen (↓) | 78 | |
| Met77Ile | acetaminophen (↑)** | 78 | |
| His149Tyr | acetaminophen (↓), O-desmethylnaproxen (↓) | 78 | |
| Tyr169Asp | acetaminophen (↓), O-desmethylnaproxen (↓) | 78 | |
| Arg213His | thyroxine (↓), acetaminophen (↓), O-desmethylnaproxen (↓) | 71, 78 | |
| Thr227Pro | acetaminophen (↓), tapentadol (↓) | 78 | |
| Val243Asp | acetaminophen (↓), O-desmethylnaproxen (↓) | 78 | |
| Fhe247Leu | acetaminophen (↑), O-desmethylnaproxen (↑) | 78 | |
| 1A3 | Ser8Pro | O-desmethyltramadol (↓), salbutamol (↓) | 128, 129 |
| Arg9Cys | norepinephrine (↓), serotonine (↓), acetaminophen (↓), morphine (↓), O-desmethyltramadol (↓) | 127, 128 | |
| Pro101Leu | ritodorine (↓), serotonine (↓) | 57, 127 | |
| Pro101His | ritodorine (↓) | 57 | |
| Arg144Cys | ritodorine (↓), serotonine (↓), acetaminophen (↓), phenylephrine (↓), | 57, 128, 129 | |
| Lys234Asn | ritodorine (↓) | 57 | |
| Asn235Thr | dopamine (↓), epinephrine (↓), norepinephrine (↓), acetaminophen (↓), morphine (↓), tapentadol (↓), O-desmethyltramadol (↓), phenylephrine (↓), salbutamol (↓) | 127, 128, 129 | |
| 1E1 | Asp22Tyr | 17β-estradiol (↓) | 12 |
| Ala34Val | 17β-estradiol (↓) | 12 | |
| Ala43Asp | estrone (↑), estriol (↑), 17β-estradiol (↓) 4-HO-tamoxifen (↓), diethylstilbestrol (↓) | 156, 157 | |
| Arg186Leu | 17β-estradiol (↓), 4-HO-tamoxifen (↓) | 156 | |
| Pro214Thr | 17β-estradiol (↓), diethylstilbestrol (↓) | 156 | |
| Asp220Val | 17β-estradiol (↓), 4-HO-tamoxifen (↓), diethylstilbestrol (↓) | 156 | |
| 2A1 | |||
| Lys44Glu | 4-androstene-3, 17-dion (↓), progesterone (↓) tibolone (↓) | 172 | |
| Ala63Pro | DHEA (↓) | 164 | |
| Pro76Thr | DHEA (↓), pregnenolone (↓), 4-androstene-3, 17-dion (↓), progesterone (↓), tibolone (↓), budesonide (↓) | 171, 172 | |
| Glu147Lys | DHEA (↓), progesterone (↓), tibolone (↓) budesonide (↓) | 171, 172 | |
| Glu148Lys | DHEA (↓), pregnenolone (↓), 4-androstene-3, 17-dion (↓), progesterone (↓), tibolone (↓) budesonide (↓) | 171, 172 | |
| Leu159Val | DHEA (↑) | 170 | |
| Lys227Glu | DHEA (↓), tibolone (↓) | 164, 170 | |
| Leu246Pro | DHEA (↓), pregnenolone (↓), 4-androstene-3, 17-dion (↓), progesterone (↓), tibolone (↓), budesonide (↓) | 171, 172 | |
| Phe258Leu | DHEA (↓), pregnenolone (↓), 4-androstene-3, 17-dion (↓), progesterone (↓), tibolone (↓), budesonide (↓) | 171, 172 | |
| Gln262Glu | DHEA (↓) | 171 | |
| 2B1 | Pro69Ala | DHEA (↓), pregnenolone (↓), cholesterol (↓) | 194, 195 |
| Gly72Val | DHEA (↓), pregnenolone (↓), cholesterol (↓) | 194, 195 | |
| Thr73Met | DHEA (↓), pregnenolone (↓), cholesterol (↓) | 194, 195 | |
| Arg147His | DHEA (↓), pregnenolone (↓), cholesterol (↓) | 194, 195 | |
| Asp191Asn | DHEA (↓), cholesterol (↓) | 193, 194, 195 | |
| Arg230His | DHEA (↓), cholesterol (↓) | 193, 194, 195 | |
| Ser244Thr | DHEA (↓), pregnenolone (↓), cholesterol (↓) | 194, 195 | |
| Arg274Gln | DHEA (↓), pregnenolone (↓), cholesterol (↓) | 194, 195 | |
| Gly276Val | DHEA (↓), pregnenolone (↓), cholesterol (↓) | 194, 195 | |
| Pro345Leu | DHEA (↓), pregnenolone (↓), cholesterol (↓) | 194, 195 |
*
(↓) refers to decreased activity toward the corresponding compounds.
**
(↑) refers to increased activity toward the corresponding compounds.