Table 3.
Summary of potential diseases related to human SULT genetic polymorphisms.
| SULT | Polymorphism | Related diseases | References |
|---|---|---|---|
| 1A1 | Arg213His | brain tumor | 69 |
| breast cancer | 82, 84 | ||
| esophageal cancer | 83 | ||
| gastric cancer | 85 | ||
| lung cancer | 86, 87, 88 | ||
| colorectal cancer (reduced risk) | 82 | ||
| bladder cancer (reduced risk) | 94 | ||
| endometrial cancer | 148, 149 | ||
| Met223Val | endometrial cancer | 149 | |
| 3’-UTR variant (rs6839, rs1042157) | endometrial cancer | 148 | |
| 1A3 | low copy number | alzheimer’s disease | 120 |
| chromosomal mutation in SULT1A3/SULT1A4 gene area (16p11.2)* | autism | 115–119, 121, 122 | |
| obesity | 123 | ||
| schizophrenia | 124 | ||
| attention deficit hyperactivity disorder | 125 | ||
| 1C4 | Asp5Glu | higher post-treatment relapse rate in acute myeloblastic leukemia | 133 |
| 1E1 | His224Gln | breast cancer | 152 |
| 5’-UTR variant (rs3736599) | endometrial cancer | 148, 149 | |
| ischemic stroke in young adults | 150 | ||
| intron variant (rs3775778) | breast cancer | 103 | |
| reduced bone mineral density | 151 | ||
| intron variant (rs3775775) | breast cancer | 103 | |
| intron variant (rs1238574) | poor survival rate of colorectal cancer | 153 | |
| intron variant (rs3822172) | poor survival rate of colorectal cancer | 153 | |
| 2A1 | intron variant (rs182420) | prostate cancer, polycystic ovary syndrome | 168, 169 |
| intron variant (rs2547238) | prostate cancer | 168 | |
| 2B1 | Arg274Gln | autosomal recessive ichthyosis | 189 |
| Arg100Trp | congenital ichthyosiform erythroderma | 190 | |
| Glu78Lys | congenital ichthyosiform erythroderma | 190 | |
| intron variant (rs4149455) | esophageal squamous cell carcinoma | 191 | |
| intron variant (rs3760806) | colorectal cancer | 153 | |
| 4A1 | 5’-UTR variant (D22s1749e) | schizophrenia | 48 |
| intron variant (rs138060) | schizophrenia | 49 | |
| intron variant (rs138097) | schizophrenia | 49 |
*
These mutations (deletion and duplication) occur in the 16p11.2 at which SULT1A3/SULT1A4 genes are located in. No potential SULT allozymes have been identified in these studies.