Table 2. Comparison of the Therapeutic Effect of Suppositories in Calves.

parameter	group 1 n = 6	group 2 n = 6	group 3 n = 6	group 4 n = 6
Average weight (kg)
day 1	44.8 ± 5	43 ± 10	41.4 ± 8	42.4 ± 10
day 11	53.5 ± 6a	47.2 ± 6	53.2 ± 7a	49.2 ± 6
Average rectal temp. °C
day 1	38.5 ± 0.6a	40.1 ± 0.3c	38.5 ± 0.3	40.5 ± 0.1c
day 2	38.5 ± 0.3	40.5 ± 0.2c	38.5 ± 0.2	39.8 ± 0.2
day 3	38.4 ± 0.3	40.2 ± 0.3c	38.3 ± 0.1	39.6 ± 0.1
day 4	38.4 ± 0.3	39.9 ± 0.2	38.6 ± 0.1	38.8 ± 0.2
day 5	38.5 ± 0.1a	39.8 ± 0.3b	39.2 ± 0.2a,b	38.7 ± 0.1
day 7	38.8 ± 0.1	39.8 ± 0.1b	38.8 ± 0.1a	38.8 ± 0.2a
day 11	38.9 ± 0.1	39.7 ± 0.2b	38.5 ± 0.1a	38.9 ± 0.1a
% of calves with diarrhea on last day of application of suppositories	0	20	0	0
mortality %	0	0	0	0
reduction in pathogenic E. coli log CFU/g	nd	no reduction	nd	0.3

^aSignificant difference (p ≤ 0.05) in comparison to Group 2.

^bSignificant difference (p ≤ 0.05) in comparison to first day of experiment.

^cSignificant differences (p ≤ 0.05) in comparison to other days of experiment. nd, not detected because no pathogenic strains of E. coli were observed in this group of healthy calves; Group 1: control healthy—healthy calves that did not receive medicine; Group 2: control positive—calves with diarrhea that did not receive medicine; Group 3: healthy calves that received medicine; Group 4: calves with diarrhea that received medicine.