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. 2021 Jun 30;7(8):2425–2436. doi: 10.1021/acsinfecdis.1c00185

Figure 2.

Figure 2

LdtMt2 time course showing that C5α-substituted carbapenems 10a (red traces), 10b (blue traces), and 13a (orange traces) fully acylate LdtMt2 after 1 h, and 13b (green traces) fully acylates LdtMt2 after 5 h as indicated by change in mass (Δm). All C5α-substituted carbapenems degrade to the Δm = +86 Da adduct on the enzyme.