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. 2021 Aug 3;12:717187. doi: 10.3389/fphys.2021.717187

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Copyright © 2021 Cheng, Zheng, Hu, Lv and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of Fis1/BAP31 prevents JNK activation and promotes cardiomyocyte survival. (A,B) Cardiomyocytes were subjected to hypoxia to mimic myocardial infarction in vitro. SiRNAs were used to attenuate Fis1 or BAP31 expression in cardiomyocytes. Then, Western blotting was used to analyze phosphorylated JNK levels in cardiomyocytes subjected to hypoxia. (C) An ELISA was used to detect JNK activity. (D) A CCK-8 assay was used to analyze the viability of cardiomyocytes. (E,F) The number of TUNEL-positive cells was measured using immunofluorescence. *p < 0.05.