Table 3. . Liver toxicity.
| Baseline | 3 months | 15 months | p-value† | |
|---|---|---|---|---|
| AST (IU/l), mean ± SD (n) | 65.3 ± 43.1 (46) | 64.6 ± 46.1 (46) | 63.8 ± 37.1 (46) | >0.05 |
| AST (IU/l), median (range) | 55.5 (18.40–204.0) | 53.5 (17.0–277.0) | 53.5 (17.0–156.0) | |
| ALT (U/l), mean ± SD (n) | 63.2 ± 50.6 (49) | 57.0 ± 42.9 (49) | 57.5 ± 40.0 (49) | >0.05 |
| ALT (U/l), median (range) | 42.0 (15.0–259.0) | 44.0 (7.0–184.0) | 47.0 (10.0–162.0) | |
| GGT (U/l), mean ± SD (n) | 105.2 ± 69.7 (44) | 143.9 ± 197.6 (44) | 166.2 ± 236.9 (44) | >0.05 |
| GGT (U/l), median (range) | 83.0 (25.0–287.0) | 82.0 (33.0–1277.0) | 96.0 (21.0–1277.0) | |
| ALK U/l), mean ± SD (n)‡ | 117.7 ± 61.4 (37) | 142.0 ± 77.4 (37) | 147.6 ± 78.0 (37) | 0.0179 |
| ALK (U/l), median (range)‡ | 97.0 (51.6–340.0) | 115.0 (69.0–393.0) | 117.0 (69.0–393.0) |
†
Change from baseline to last follow-up.
‡
Two values <35 U/l were considered outliers and excluded from the analyses.
ALK: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; SD: Standard deviation.