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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Vet Pathol. 2020 Nov 18;58(1):205–222. doi: 10.1177/0300985820960128

Figure 43.

Figure 43.

Ionized calcium binding adaptor molecule 1 (Iba1) immunolabeling in the cervical spinal cord and dorsal root ganglion (DRG) of control (Ct) and mucopolysaccharidosis (MPS) IIIB (IIIB) dogs. The data shown represents Iba1 immunolabeling in each ROI as determined by pixel-based analysis (% positive tissue labeled). Mean Iba1 immunolabeling was increased in both the ventral horn and lateral funiculus of the cervical spinal cord in 4-month-old dogs with MPS IIIB and was increased in all subsequent time points. No difference in Iba1 immunolabeling was observed in the DRG between the control dog and the 2 months old dog with MPS IIIB. Iba1 immunoreactivity was markedly increased in 18- and 26-month-old dogs with MPS IIIB.