Figure 20-27.

Mucopolysaccharidosis IIIB, cerebral cortex (Figs 20-23) and cervical spinal cord (Figs 24-27), dog. Immunohistochemistry for glial fibrillary acidic protein (GFAP). Samples are from dogs aged 4 (Fig. 20, 24), 10 (Fig. 21, 25), 18 (Fig. 22, 26), and 26 (Fig. 23, 27) months. Subjectively, there is increased GFAP immunolabeling (brown) in both the cerebral cortex and cervical spinal cord observed at each of the increasing time points with the greatest immunolabeling being observed at 26 months of age.