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. 2021 Aug 3;12:696461. doi: 10.3389/fphar.2021.696461

FIGURE 6.

FIGURE 6

Dose-dependent effects of acute and repeated kratom administration on NAc-PFC, NAc-Cg, and PFC-Cg coherence. Coherence across frequencies and quantification showing the effect of acute and repeated low (0.5 mg/kg) or high (1 mg/kg) dose kratom 30 min post-injection. Data shown were taken from 30 s epochs. (A) On day 1, both doses of kratom increased NAc-PFC delta and high gamma coherence. Low dose kratom increased theta coherence and high dose kratom increased beta and low gamma coherence. (B) On day 7, both doses of kratom increased delta coherence whereas only high dose kratom induced an increase in high gamma coherence. (C) On day 1, high dose kratom increased low gamma NAc-Cg coherence whereas low dose kratom increased high gamma coherence. (D) NAc-Cg coherence was increased in the high gamma frequency band only in response to low dose kratom on day 7. (E) Low dose kratom increased low frequency and low gamma coherence between the PFC-Cg. High dose kratom also increased coherence in the low gamma frequency band on day 1. (F) On day 7, only low dose kratom elevated PFC-Cg low and high gamma coherence. N = 7–10 rats per group, with 2 electrodes/rat. Curves are represented as means with jackknife estimates of sem depicted by the shaded areas. Quantification of coherence are represented as boxplots with min/max values. *p < 0.05, **p < 0.01, ***p < 0.001 compared to saline control rats. # p < 0.05 compared to low dose kratom treated rats.