TABLE 2.

The enrichment analysis of candidate hub genes.

Term ID	Term description	Count	False discovery rate	Matching proteins in network
hsa04310	Wnt signaling pathway	6	5.29E–07	SFRP5, WNT9A, SFRP2, WIF1, WNT11, FZD3
hsa04060	Cytokine–cytokine receptor interaction	4	0.0012	ACKR3, CCR10, IL6, CCR3
hsa04151	PI3K–Akt signaling pathway	4	0.0025	ERBB3, ERBB2, IL6, BDNF
GO:0060028	Convergent extension involved in axis elongation	2	0.0004	SFRP2, WNT11
GO:0048570	Notochord morphogenesis	2	0.00074	GLI1, WNT11
GO:1900122	Positive regulation of receptor binding	2	0.00087	MMP9, BDNF
GO:0004888	Transmembrane signaling receptor activity	10	4.75E–06	SFRP5, ERBB3, ERBB2, ACKR3, SFRP2, GPR37, CCR10, FZD3, CCR3, S1PR2
GO:0017147	Wnt-protein binding	4	4.75E–06	SFRP5, SFRP2, WIF1, FZD3
GO:0038023	Signaling receptor activity	11	4.75E–06	SFRP5, ERBB3, ERBB2, ACKR3, SFRP2, GPR37, CCR10, AR, FZD3, CCR3, S1PR2
GO:0005576	Extracellular region	11	0.00085	SFRP5, ERBB3, WNT9A, SFRP2, WIF1, PNOC, WNT11, MMP9, DKK3, IL6, BDNF
GO:0005615	Extracellular space	8	0.00085	SFRP5, ERBB3, WNT9A, SFRP2, WNT11, MMP9, DKK3, IL6
GO:0043235	Receptor complex	4	0.0081	ERBB3, ERBB2, GPR37, IL6

SFRP5, secreted frizzled-related protein 5; WNT9A, protein Wnt-9a; SFRP2, secreted frizzled-related protein 2; WIF1, Wnt inhibitory factor 1; WNT11, protein Wnt-11; FZD3, frizzled-3; ACKR3, atypical chemokine receptor 3; CCR10, C-C chemokine receptor type 10; IL6, interleukin-6; CCR3, C-C chemokine receptor type 3; ERBB3, receptor tyrosine-protein kinase erbB-3; ERBB2, receptor tyrosine-protein kinase erbB-2; BDNF, brain-derived neurotrophic factor; GLI1, zinc finger protein GLI1; MMP9, matrix metalloproteinase-9; GPR37, prosaposin receptor GPR37; S1PR2, sphingosine 1-phosphate receptor 2; AR, androgen receptor; PNOC, prepronociceptin; DKK3, dickkopf-related protein 3.