Table 4.
HOAMS (semi-quantitative MRI) outcomes: Changes over 12 months. Values are number (%), unless otherwise indicated
| MRI feature/category | Arthroscopy N = 42 |
PHT N = 43 |
Difference, % (95% CI) | P-value |
|---|---|---|---|---|
| Cartilage | ||||
| Change across all regions (excluding within-grade change): | ||||
| No change | 29 (69%) | 43 (100%) | 0.0002a | |
| Worsening in 1 subregion | 11 (26%) | 0 | ||
| Worsening in 2 subregions | 2 (5%) | 0 | ||
| Any worsening | 13 (31) | 0 | 31 (15–47) | |
| Change across all regions (including within-grade change): | ||||
| Improvement in 1 subregion+ worsening in 1 subregion | 1 (2%) | 0 | ||
| No change | 26 (62%) | 41 (95%) | ||
| Worsening in 1 subregion only | 11 (26%) | 2 (5%) | ||
| Worsening in 2 subregions only | 3 (7%) | 0 | ||
| Worsening in 3+ subregions only | 1 (2%) | 0 | ||
| Any worsening | 16 (38%) | 2 (5%) | 33 (15–52) | 0.0002b |
| BML | ||||
| Change in no. of subregions affected by any lesion: | ||||
| Improvement | 1 (2%) | 1 (2%) | 0.61a | |
| No change | 38 (91%) | 40 (93%) | ||
| Worsening in 1 subregion | 1 (2%) | 2 (5%) | ||
| Worsening in 2 subregions | 2 (5%) | 0 | ||
| Maximum change in BML score across all subregions: | ||||
| No changec | 37 (88%) | 40 (93%) | 0.66a | |
| Within-grade worsening | 2 (5%) | 0 | ||
| Worsening by 1 grade | 3 (7%) | 3 (7%) | ||
| Any subregion with improvement (including within-grade changes) in BML | 2 (5%) | 4 (9%) | −4 (−18–9) | |
| Any subregion with worsening (including within-grade changes) in BML | 5 (12%) | 3 (7%) | 5 (−10–20) | |
| Subchondral cyst | ||||
| Change in no. of subregions affected: | ||||
| Improvement | 5 (12%) | 0 | 0.11a | |
| No change | 33 (78%) | 39 (91%) | ||
| Worsening in 1 subregion | 4 (10%) | 3 (7%) | ||
| Worsening in 2 subregions | 0 | 0 | ||
| Worsening in 3 subregions | 0 | 1 (2%) | ||
| Maximum change in score across all subregions: | ||||
| No changec | 38 (90%) | 37 (86%) | 0.75a | |
| Within-grade worsening | 0 | 2 (5%) | ||
| Worsening by 1 grade | 4 (10%) | 4 (9%) | ||
| Any subregion with improvement (including within-grade changes) | 7 (17%) | 3 (7%) | 10 (−6–26) | |
| Any subregion with worsening (including within-grade changes) | 4 (10%) | 6 (14%) | −4 (−20–12) | |
| Osteophyte | ||||
| Increase in no. locations affected by any osteophyte: | 0 | 0 | ||
| Change in no. of locations affected by any osteophyte: | ||||
| Improvement 1 subregion | 6 (14%) | 0 | 0.01b | |
| No Change | 36 (86%) | 42 (100%) | ||
| Maximum change in osteophyte score ≥ 1 across all subregions: | 0 | 0 | ||
| Labrum | ||||
| Maximum change in score across all subregions: | ||||
| No changec | 17 (40%) | 34 (81%) | 0.0009a | |
| Within-grade worsening | 12 (29%) | 3 (7%) | ||
| Worsening by 1 grade | 11 (26%) | 5 (12%) | ||
| Worsening by 2 grades | 2 (5%) | 0 | ||
| Any subregion with improvement (including within-grade changes) | 7 (17%) | 2 (5%) | 12 (−3–27) | |
| Any subregion with worsening (including within-grade changes) | 25 (60%) | 8 (19%) | 40 (19–62) | |
| Synovitis | ||||
| Maximum change in score across all subregions: | ||||
| No changec | 14 (33%) | 23 (58%) | 0.08a | |
| Within-grade worsening | 7 (17%) | 5 (12%) | ||
| Worsening by 1 grade | 19 (45%) | 11 (28%) | ||
| Worsening by 2 grades | 2 (5%) | 1 (2%) | ||
| Any subregion with improvement (including within-grade changes) | 10 (24%) | 10 (24%) | −0 (−21–20) | |
| Any subregion with worsening (including within-grade changes) | 28 (67%) | 17 (41%) | 25 (2–48) | |
aOrdinal chi-squared test
bChi-squared test
cIncludes within-grade improvement