Fig. 2.

AICAP consists with known physicochemical properties involved in phase separation. A Schematic of 1,6-HD treatment and definition of AICAP. B Scatter plot of proteins with AICAP values 0~2 captured by Hi-MS. C The disorder compositions of 6 groups of proteins. IDR, intrinsically disorder region; LCD, low complexity domain. D The Spearman correlation between AICAP and corresponding residue percentage in proteins with AICAP < 1. Each column panel refers to residue percentage in different regions (whole sequence, whole sequence minus IDR, IDR, and PLD). PLD, prion-like domain. E The LLPS predictor scores of 6 groups of proteins