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. 2021 Aug 17;22:229. doi: 10.1186/s13059-021-02456-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — A/B compartment of chromatin exhibited different sensitivities to 1,6-HD treatment. A A (red) and B (blue) compartments can be classified into 4 compartment change-types as strengthened, stable, weakened based on their PC1 value ratio (1,6-HD+/−). 20% was chosen as the threshold for distinguishing stability or not. B The fraction of four kinds of compartment change-types. C Contact probability between compartments along genomic distance. D Examples of strengthened/stable compartments and corresponding nuclear speckle/lamina TSA-seq [39] plots. The plotting of log2 ratio of TSA read density versus input read density was used to measure the distance from a chromatin region to a specific nuclear condensate. Chr2, 0–80 M. E AICAP values of nuclear speckle and lamina associated proteins. Data resource [40, 41]