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VU6021625 does not increase locomotor activity in normal, drug naïve rodents. Unlike scopolamine (3 mg/kg, i.p.), VU6021625 (3 mg/kg, i.p.) does not increase locomotor activity in either mice (A, B) or rats (C, D) (A, C, time activity curve; B, D, total distance traveled after vehicle, VU6021625, or scopolamine administration). Mouse N = 12 per group. Rat N = 8 per group. One way ANOVA with Dunnett’s posthoc test **p < 0.01, ***p < 0.001; NS, not significant.
