Skip to main content
. 2021 Aug 2;4(4):1306–1321. doi: 10.1021/acsptsci.0c00162

Table 3. Pharamacokinetic–Pharmacodynamic Relationship of VU6021625a.

VU6021625 HIC dose response
dose (mg/kg) brain unbound (nM)
0.3 4.8
1 12.3
3 34.2
a

Unbound brain drug concentrations of VU6021625 after catalepsy testing. At the minimally efficacious dose (1 mg/kg), drug exposure reaches levels that are consistent with selectivity in vitro. Data derived from graphs in Figure 3C,D. N = 8–10 per condition.