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. Author manuscript; available in PMC: 2021 Aug 17.
Published in final edited form as: Nat Immunol. 2011 Apr 10;12(5):399–407. doi: 10.1038/ni.2021

Figure 4.

Figure 4

Augmented repopulation activity of Itch−/− HSCs show after myeloablation. (a) Distribution of LSK cells in wild-type and Itch−/− bone marrow (n = 5 mice per group) after injection of 5-FU. (b) Differential blood counts and hematocrit (HCT) of wild-type and Itch−/− mice (n = 5 per group) after injection of 5-FU. RBC, red blood cell. *P < 0.05 (Student’s t-test). (c) Survival of wild-type recipients (n = 10 per group) of wild-type or Itch−/− bone marrow cells, assessed with a log-rank nonparametric test after sequential 5-FU treatment and presented as a Kaplan-Meier survival curve. P = 0.0082 (Student’s t-test). Data are representative of two independent experiments (mean ± s.e.m. in b).