Table 1.
Efficacy inputs with medication discontinuation at 8.6 months [Source: elaborated from Samuelson et al 2019 [16]]
| Time (years) | iStent + Cataract surgery | Cataract surgery | ||
|---|---|---|---|---|
| IOP (mmHg) | IOP reduction (mmHg)a | IOP (mmHg) | IOP reduction (mmHg)a | |
| 0 | 24.8b | – | 24.5** | – |
| 1 | 17.7 | 7.1b | 19.0 | 5.5b |
| 2 | 18.3 | 6.6b | 20.1 | 4.4b |
| 3 | 19.1 | 5.7 | 20.9 | 3.6 |
| 4 | 19.4 | 5.4 | 21.2 | 3.3 |
| 5 | 19.7 | 5.1 | 21.3 | 3.2 |
| 6 | 20.0 | 4.8 | 21.5 | 3.0 |
| 7 | 20.3 | 4.5 | 21.7 | 2.8 |
| 8 | 20.5 | 4.3 | 21.8 | 2.7 |
| 9 | 20.8 | 4.0 | 22.0 | 2.5 |
| 10 | 21.0 | 3.8 | 22.1 | 2.4 |
| 10+ | 21.2 | 3.6 | 22.2 | 2.3 |
IOP intraocular pressur
Values after 2 years are based on expert opinions
aIntraocular pressure reduction vs. baseline
bIOP and IOP reduction data, at one and two years, were obtained from the randomized clinical trial (RCT) conducted by Samuelson et al 2019 [16] and adjusted for the time-to-discontinuation. Baseline IOP: 24.8 ± 3.3 mmHg vs. 24.5 ± 3.1 mmHg in the iStent + Cataract surgery vs. Cataract surgery groups, respectively (P = 0.33)