Table 2.
Cost input included in the analysis
| Type | Description | Value | Source |
|---|---|---|---|
| Main procedures | Glaucoma + cataract surgery cost (€) | €2294.20 | iStent acquisition cost + procedures cost [34–37] |
| Cataract surgery cost (€) | €994.00 | DH 39 [38] | |
| Subsequent procedures | Trabeculectomy cost (€) | €1969.10 | Code 12.64 [35, 39, 40] |
| Medications | Bimatoprost cost (€) | €20.23 | Generic ex-factory price [41] |
| Bimatoprost + timolol cost (€) | €27.25 | Branded ex-factory price [42] | |
| Brinzolamide + timolol cost (€) | €16.88 | Branded ex-factory price [42] | |
| Dorzolamide + timolol cost (€) | €7.33 | Generic ex-factory price [41] | |
| Travoprost + timolol cost (€) | €18.26 | Generic ex-factory price [41] | |
| Timolol cost (€) | €5.70 | Generic ex-factory price [41] | |
| Tafluprost cost (€) | €25.94 | Branded ex-factory price [42] | |
| Bimatoprost MS (%) | 15.6% | [43] | |
| Bimatoprost + timolol MS (%) | 11.5% | ||
| Brinzolamide + timolol MS (%) | 13.9% | ||
| Dorzolamide + timolol MS (%) | 16.4% | ||
| Travoprost + timolol MS (%) | 6.6% | ||
| Timolol MS (%) | 25.4% | ||
| Tafluprost MS (%) | 10.7% | ||
| Disease monitoring | Ophthalmologist consultation cost (€) | €20.66 | Code 95.02 [44] |
| Gonioscopy cost (€) | €7.75 | Code 95.26 [44] | |
| VF defect test cost (€) | €16.78 | Code 95.05 [44] | |
| Optic disc imaging cost (€) | €90.00 | Code: 95.17 [36] | |
| Incidence ophthalmologist consultation (n/month), mild glaucoma | 0.17 | [26] | |
| Incidence ophthalmologist consultation (n/month), moderate glaucoma | 0.25 | ||
| Incidence ophthalmologist consultation (n/month), advanced glaucoma | 0.33 | ||
| Incidence ophthalmologist consultation (n/month), severe/blind glaucoma | 0.25 | ||
| Incidence gonioscopy (n/month), mild glaucoma | 0.08 | ||
| Incidence gonioscopy (n/month), moderate glaucoma | 0.08 | ||
| Incidence gonioscopy (n/month), advanced glaucoma | 0.08 | ||
| Incidence gonioscopy (n/month), severe/blind glaucoma | 0.08 | ||
| Incidence VF defect test (n/month), mild glaucoma | 0.17 | ||
| Incidence VF defect test (n/month), moderate glaucoma | 0.17 | ||
| Incidence VF defect test (n/month), advanced glaucoma | 0.25 | ||
| Incidence VF defect test (n/month), severe/blind glaucoma | 0.17 | ||
| Incidence optic disc imaging (n/month), mild glaucoma | 0.17 | ||
| Incidence optic disc imaging (n/month), moderate glaucoma | 0.17 | ||
| Incidence optic disc imaging (n/month), advanced glaucoma | 0.33 | ||
| Incidence optic disc imaging (n/month), severe/blind glaucoma | 0.17 | ||
| Adverse events | Hyperaemia unit cost (€) | €20.66 | Code 89.07 [44] |
| Stent obstruction unit cost (€) | €1522.00 | DH 42 [38] | |
| Incidence hyperaemia, iStent + cataract group (%) | 0.8% | [45] | |
| Incidence stent obstruction, iStent + cataract group (%) | 6.2% | ||
| Incidence hyperaemia, cataract surgery only group (%) | 5.9% | ||
| Incidence stent obstruction, cataract surgery only group (%) | 0.0% |
DH day hospital, MS market share, VF visual field