Table 4.

Species with significant correlations with the highest aMED Scores (> 6)

Genus_Species	Correlation (r)	p-value	Metabolic Production and Physiologic Effects cited in literature
Lactobacillus_rogosae	0.277	0.007	Decreased in women with Gestational Diabetes [23]
Coprococcus_eutactus	0.256	0.012	Actively ferments carbohydrates, produces butyric and acetic acids with formic or propionic and/or lactic acid [24]
Phascolarctobacterium_faecium	0.243	0.018	Produces short-chain fatty acids, including acetate and propionate, upregulated by metformin in animal models [25]
Anaerococcus_tetradius	0.242	0.018	Primarily found in vagina and female reproductive tract. Ferments glucose and mannose, butyrate is an end-product [26]
Collinsella_aerofaciens	0.235	0.022	Unique collinsella species with butyrate kinase [27]
Alistipes_sp.	0.229	0.025	Negative correlation with glucose intolerance in pregnancy [28]
Faecalibacterium_prausnitzii	0.205	0.046	Butyrate producing, Anti-inflammatory properties, associated with low secretion of pro-inflammatory cytokines (IL-12 and IFN-γ), and elevated secretion of the anti-inflammatory cytokine IL-10 [36, 38, 39].
Pseudobutyrivibrio_ruminis	0.202	0.050	Butyrate producer [23]