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. 2021 Aug 17;19:353. doi: 10.1186/s12967-021-03018-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — miR-525-5p downregulates FGF11 expression and inhibits NSCLC cell proliferation and migration. A Bioinformatic search of miRNAs targeting FGF11 using miRDB, Starbase and Targetscan databases. B qPCR analysis of FGF11 mRNA expression in A549 and NCI-H460 cells in the presence of microRNA mimics. c Dual-luciferase reporter assay of the effect of miR-525-5p mimic on FGF11 3′UTR. D western blot detected the expression of FGF11 after transfected with miR-525-5p. E qPCR analysis of the FGF11 mRNA level in NSCLC tumor tissues and normal tissues. F The correlation of miR-525-5p level and FGF11 level was examined by Pearson’s correlation analysis. G CCK-8 proliferation assay of A549 and NCI-H460 cells transfected with miR-525-5p and/or FGF11. H Colony formation assay in A549 and NCI-H460 cells transfected with miR-525-5p and/or FGF11. I Wound healing assay in A549 and NCI-H460 cells transfected with miR-525-5p and/or FGF11. J Transwell migration assay in A549 and NCI-H460 cells transfected with miR-525-5p and/or FGF11. The results are represented as mean ± standard derivation. Data are summary of 3 independent experiments. *P < 0.05, ** P < 0.01, ***P < 0.005 vs. sh-NC or empty vector-transfected cells