TABLE 1.
Presenting clinical characteristics of patients with T-ALL on DFCI 05-001 and 11-001
| Patient Characteristic | N (%) | non ETP T-ALL N (%) |
ETP-ALL* N (%) |
p-value† |
|---|---|---|---|---|
| No. Pts. | 123‡ | 100 | 21 | |
| Protocol | ||||
| 05-001 | 97 (79) | 78 (78) | 17 (81) | 0.99 |
| 11-001 | 26 (21) | 22 (22) | 4 (19) | |
| Age | ||||
| <10 yrs | 67 (54) | 58 (58) | 7 (33) | 0.054 |
| ≥10 yrs | 56 (46) | 42 (42) | 14 (67) | |
| median (range) yrs. | 8.5 (1.2, 17.9) | 8.2 (1.2, 18) | 11.1 (2.9, 17.9) | 0.086 |
| Sex | ||||
| Male | 91 (74) | 77 (77) | 13 (62) | 0.17 |
| Female | 32 (26) | 23 (23) | 8 (38) | |
| WBC | ||||
| <50 K | 53 (43) | 35 (35) | 17 (81) | 0.0002 |
| ≥50 K | 70 (57) | 65 (65) | 4 (19) | |
| median (range) | 62.4 (0.9, 905.0) | 81.1 (1.1, 905.0) | 13.4 (1.0, 259.2) | 0.0001 |
| Mediastinal Mass | ||||
| Yes | 55 (45) | 48 (48) | 6 (29) | 0.15 |
| No | 68 (55) | 52 (52) | 15 (71) | |
| CNS Status | ||||
| 1 | 71 (58) | 59 (59) | 11 (52) | 0.76 |
| 2 | 42 (34) | 33 (33) | 8 (38) | |
| 3 | 10 (8) | 8 (8) | 2 (10) | |
*
Includes 1 case of probable ETP, which was not assessed for CD1a status
†
Comparison of non ETP-ALL and ETP-ALL
‡
Of the 123 patients with T-ALL enrolled, sufficient data to evaluate ETP status was available for 121 patients