FIGURE 1.

ZnT8 deficiency ameliorates APAP-induced liver injury. Mice were treated with 300 mg/ kg APAP and sacrificed 24 h after APAP treatment. (A) Gross morphology of the livers. (B) Liver weights. (C) Representative H and E stained images. (D) Quantification of necrotic area. (E) Serum ALT and AST activities. (F) Immunoblotting and quantification of pJNK and total JNK in the liver. Data are represented as mean ± SEM. *, p < 0.05, **, p < 0.01 by the two-way ANOVA and post hoc Bonferroni’s multiple comparison test.