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Oxidative stress is reduced in the liver of APAP-treated ZnT8 KO mice. Hepatic levels of GSH (A), MDA (B), and SOD (C). (D) Immunoblotting and quantification of 4-HNE in the liver. (E) Immunoblotting and quantification of CYP4A and CYP2E1 in liver. GAPDH was used as an internal control. Data are represented as mean ± SEM. *, p < 0.05, ***, p < 0.001 by the one-way ANOVA test or unpaired Student’s t-test. NS, not significant.
