KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Raptor	Cell Signaling Technology	Cat# 2280; RRID: AB_561245
ACC	Cell Signaling Technology	Cat# 3676; RRID: AB_2219397
ACLY	Cell Signaling Technology	Cat# 4332; RRID: AB_2223744
FASN	Cell Signaling Technology	Cat# 3180; RRID: AB_2100796
α-Tubulin	Cell Signaling Technology	Cat# 2125; RRID: AB_2619646
PPARγ	Santa Cruz biotechnology	Cat# sc-7273; RRID: AB_628115
UCP1	Abcam	Cat# ab10983; RRID: AB_2241462
Chemicals, peptides, and recombinant proteins
D-GLUCOSE (U-13C6, 99%)	Cambridge Isotope Laboratories	Cat#CLM-1396-PK
[1,2-3H]-deoxy-D-glucose	Perkin Elmer	NET328A001MC
Critical commercial assays
Glucose meter	Bionime	GE100
Ultrasensitive insulin ELISA kit	Crystal Chem	90060
Deposited data
Data S1. Isotope tracing and Metabolomics upon temperature acclimation, related to Figures 1, 2, 3, 4, 5, 6, and S1-S9	This Study	Supplemental information
Data S2. Isotope tracing and Metabolomics upon acute cold, related to Figures 7 and S10	This Study	Supplemental information
RNA sequencing raw data upon temperature acclimation, related to Figures 2, 4, S3-S5, S7, and S8	Sanchez-Gurmaches et al., 2018 (PMID: 29153407)	NCBI Gene Expression Omnibus: GSE96681
Experimental models: Organisms/Strains
Mouse: C57BL/6	Jackson labs	000664
Software and algorithms
Graphpad	GraphPad Software	Graphpad.com
Adobe Illustrator	Adobe	Adobe.com
MAVEN software	http://genomics-pubs.princeton.edu/mzroll/index.php	N/A
MetaboAnalyst 3.0, 4.0, 5.0	https://www.metaboanalyst.ca	N/A
Other
Rodent incubators	Power Scientific	RIT33SD