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. 2021 Apr 10;5(8):1412–1425. doi: 10.1002/hep4.1723

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© 2021 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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FIG. 4 — Pharmacological effect (mean ± SD) of pioglitazone, PXL065, and d‐S‐pio after 10 days of once‐daily dosing of vehicle, pioglitazone (30 mg/kg), PXL065 (20 mg/kg), or d‐S‐pio (20 mg/kg) by oral gavage in the db/db mouse model on inflammatory markers serum amyloid A and cytokines IL‐1β and IL‐6 (A), serum adiponectin (B), serum TGs, and FFAs (C): vehicle, black; pioglitazone, blue; d‐S‐pio, red; and PXL065, green. Significantly different from vehicle: *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.