FIG. 1.

Association of SERPINA1 Z allele with cirrhosis phenotype by ICD‐10 diagnostic codes in UK Biobank, using the Firth penalized likelihood approach. ORs were calculated with the use of logistic regression, with adjustment for age, sex, BMI, total number of medications, genotyping batch, and first 10 principal components of ancestry. Subjects were coded 0 for reference allele homozygotes, 1 for heterozygotes, and 2 for alternate allele homozygotes. The first panel reflects an additive (per allele) model and the second and third panels reflect genotypic ORs for SERPINA1 Z allele heterozygotes (C/T) and homozygotes (T/T), respectively. The table reflects the number of subjects with and without cirrhosis for each genotype.