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. 2021 Apr 3;5(8):1348–1361. doi: 10.1002/hep4.1718

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© 2021 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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FIG. 3 — Association of PNPLA3 I148M, and TM6SF2 E167K with cirrhosis phenotype by ICD‐10 diagnostic codes in the UK Biobank genotypic model, using the Firth penalized likelihood approach. Genotypic ORs are shown for PNPLA3 I148M heterozygotes (C/G) and homozygotes (G/G) as well as for TM6SF2 E167K heterozygotes (C/T) and homozygotes (T/T). ORs were calculated with the use of logistic regression, with adjustment for age, sex, BMI, total number of medications, genotyping batch, and first 10 principal components of ancestry.