FIG. 5.

Association of PNPLA3 I148M, the SERPINA1 Z allele, and TM6SF2 E167K with cirrhosis by ICD‐10 diagnostic codes in the Mass General Brigham Biobank additive (per allele) model, using the Firth penalized likelihood approach. ORs were calculated with the use of logistic regression, with adjustment for age, sex, BMI, genotyping batch, and first 10 principal components of ancestry. Subjects were coded 0 for reference allele homozygotes, 1 for heterozygotes, and 2 for alternate allele homozygotes. The table reflects the number of subjects with and without cirrhosis for each genotype.