Table 1.
Characteristics of subjects with and without cirrhosis by ICD‐10 codes in UK Biobank
| No Cirrhosis (n = 311,178) | Cirrhosis (n = 1,493) | Total (N = 312,671) | P Value | |
|---|---|---|---|---|
| Age (years) | 56.85 (7.98) | 58.98 (7.10) | 56.86 (7.98) | <0.001 |
| Sex (male) | 144,170 (46%) | 1,011 (68%) | 145,181 (46%) | <0.001 |
| BMI (kg/m2) | 26.70 [24.12, 29.82] | 28.54 [25.43, 32.52] | 26.70 [24.12, 29.83] | <0.001 |
| Waist (cm) | 90.33 (13.39) | 99.09 (14.53) | 90.37 (13.41) | <0.001 |
| Number of Medications | 2.00 [0.00, 4.00] | 4.00 [2.00, 7.00] | 2.00 [0.00, 4.00] | <0.001 |
| ALT (U/L) | 20.16 [15.47, 27.31] | 29.97 [20.40, 48.06] | 20.18 [15.48, 27.37] | <0.001 |
| AST (U/L) | 24.40 [21.00, 28.80] | 36.30 [26.10, 57.00] | 24.40 [21.00, 28.80] | <0.001 |
| GGT (U/L) | 26.20 [18.50, 40.70] | 75.00 [35.80, 192.38] | 26.20 [18.50, 40.90] | <0.001 |
| ALP (U/L) | 80.30 [67.30, 95.60] | 96.93 [77.97, 126.90] | 80.30 [67.30, 95.70] | <0.001 |
| Total bilirubin (µmol/L) | 8.08 [6.45, 10.41] | 9.96 [7.49, 14.32] | 8.09 [6.45, 10.43] | <0.001 |
| Direct bilirubin (µmol/L) | 1.61 [1.30, 2.08] | 2.26 [1.64, 3.51] | 1.61 [1.30, 2.09] | <0.001 |
| Platelets (109 cells/L) | 247.80 [213.30, 286.50] | 204.30 [156.70, 260.00] | 247.60 [213.00, 286.30] | <0.001 |
| Albumin (g/L) | 45.26 (2.59) | 43.49 (3.88) | 45.26 (2.60) | <0.001 |
| FIB‐4 | 1.24 [0.98, 1.57] | 1.91 [1.33, 3.16] | 1.25 [0.98, 1.58] | <0.001 |
| Weekly alcohol use | 12.00 [6.00, 22.00] | 20.00 [9.00, 40.00] | 12.00 [6.00, 22.00] | <0.001 |
| LDL (mmol/L) | 3.57 (0.87) | 3.16 (0.92) | 3.57 (0.87) | <0.001 |
| HDL (mmol/L) | 1.46 (0.38) | 1.35 (0.45) | 1.45 (0.38) | <0.001 |
| Cholesterol (mmol/L) | 5.72 (1.14) | 5.15 (1.28) | 5.72 (1.14) | <0.001 |
Mean (SD) or number (%) are reported for normal variables and median [interquartile range] for non‐normal variables. Comparisons are made using the t test for normal variables and the Kruskal‐Wallis test for non‐normal variables. FIB‐4 is a noninvasive marker of hepatic fibrosis calculated by age × AST [U/L] / (PLT [109/L] × ALT1/2 [U/L]).( 30 ) Alcohol use is defined by average units of alcohol consumed per week among subjects reporting alcohol use.
Abbreviations: HDL, high‐density lipoprotein; PLT, platelet.