Table 2.

Association of genetic variants with biomarkers of liver injury in SERPINA1 Z allele (Pi*Z) heterozygotes and homozygotes (Pi*ZZ) in UK Biobank

Pi*Z heterozygotes	Measure (U/L)	Estimate	SE	Pr (>|t|)
	log ALT	5.43e−02	3.81e−03	4.64e−46
	log AST	2.67e−02	2.47e−03	2.23e−27
	log ALP	3.46e−02	2.51e−03	3.26e−43
	log GGT	2.31e−02	5.28e−03	1.21e−05
	log total bilirubin	1.56e−02	3.46e−03	6.35e−06

Pi*ZZ homozygotes	Measure (U/L)	Estimate	SE	Pr (>|t|)
	log ALT	1.37e−01	3.75e−02	2.66e−04
	log AST	1.85e−01	2.43e−02	2.72e−14
	log ALP	6.03e−02	2.47e−02	1.45e−02
	log GGT	1.81e−01	5.22e−02	5.43e−04
	log total bilirubin	4.97e−02	3.41e−02	1.45e−01

Linear regression was performed adjusting for age, sex, BMI, number of medications, batch, and the first 10 principal components of ancestry.

Abbreviations: Pr (>|t|), P value for the proportion of the t distribution that is greater than the absolute value of the t statistic; SE, standard error.